Validation of VCF files

VarSome Clinical accepts any VCF file, however it must conform to the standards for VCF files. The issue is usually a malformed header or a missing header.

You may use one these validators:

Basically, the VCF file needs to follow the VCF standard correctly. Another quick test is to just see if a standard program like bcftools ( recognizes the file and doesn't complain.