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VarSome supports queries about gene fusions and provides the name of the fusion and a summarized view of clinically relevant information for a selected fusion through the OncoKB card.
OncoKB card is available only in VarSome Premium subscriptions.
Fusion Details card
If you include the breakpoints in your query, you will be able to see the gene symbols of the fusion partners in the Fusion Details card, along with the breakpoint coordinates for each gene.
When breakpoint information is available, a graphical representation of the fusion is also provided. This visualization illustrates the breakpoint positions within the chromosomes, their locations within each transcript, and the resulting fused product.
OncoKB card (for VarSome Premium subscriptions only)
The card displays the OncoKB title, a variant summary icon, and key annotations including Oncogenicity, Mutation Effect, and the Therapeutic, Diagnostic, and Prognostic levels of evidence.
By clicking on the card, users can access the detailed OncoKB component, which mirrors the layout and content of the OncoKB website for the selected fusion.
VarSome includes information from FusionGDB database as well. This information can be retrieved when querying a gene in VarSome, e.g.:
FusionGDB is the Fusion Gene annotation database, aiming to provide a resource or reference for functional annotation of fusion genes in cancer for better therapeutic targets.
VarSome shows the list of gene fusions associated to the gene of interest.
The list of related drugs and disease associations are also shown in the Fusion GDB tab:
