---
title: Dynamic filters
description: "It is possible to create a filter set directly from the analysis results or from the “Filter sets” menu. From the analysis results:   A pop-up window called Filter set will appear. This window is spli"
---

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1. [VarSome Help Center](https://docs.varsome.com/en?hsLang=en)
2. [Analysis of the results](https://docs.varsome.com/en/analysis-of-the-results?hsLang=en)
3. [Filters](https://docs.varsome.com/en/analysis-of-the-results?hsLang=en#filters)

# Dynamic filters

## VarSome Clinical introduces the full functionality of our redesigned filtering experience, featuring intuitive AND/OR logic for more flexible, precise filtering of clinically relevant variants.

The new filter builder gives you full control over how filters relate to one another. Previously, all filters were joined by AND logic only, now each filter is independent, and you can define **AND/OR** relationships between individual filters and groups of filters. 

Our new filtering system is available in the analysis page by clicking on **Filters** and from our **Filter** **sets** page. The new re-designed filter configuration can be opened by clicking on the **Filters** button.

[![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-05-2026-11-08-36-5235-AM.png?width=670&height=163&name=image-png-Oct-05-2026-11-08-36-5235-AM.png)](https://docs.varsome.com/hubfs/image-png-Oct-05-2026-11-08-36-5235-AM.png?hsLang=en)

Our **Filter sets** page allows you to view your saved filter sets and the shared ones, check the analysis associated to each filter, edit filters and create new filters sets by analysis type. 

[![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-05-2026-11-10-52-4067-AM.png?width=670&height=65&name=image-png-Oct-05-2026-11-10-52-4067-AM.png)](https://docs.varsome.com/hubfs/image-png-Oct-05-2026-11-10-52-4067-AM.png?hsLang=en)

![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-05-2026-11-13-06-3244-AM.png?width=670&height=194&name=image-png-Oct-05-2026-11-13-06-3244-AM.png)

[![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-05-2026-11-13-44-6938-AM.png?width=670&height=436&name=image-png-Oct-05-2026-11-13-44-6938-AM.png)](https://docs.varsome.com/hubfs/image-png-Oct-05-2026-11-13-44-6938-AM.png?hsLang=en)

You can create the following filter sets:

- Create New Set
- Create New Set (SV & CNV Results): specific filter sets for SV & CNV analysis’ results.
- Create New Set (RE Results): specific filter sets for Repeat expansion analysis’ results.
- Create New Set (Fusion Results): specific filter sets for Fusion analysis’ results.

#### [![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-08-23-03-0322-AM.png?width=670&height=123&name=image-png-Oct-02-2026-08-23-03-0322-AM.png)](https://docs.varsome.com/hubfs/image-png-Oct-02-2026-08-23-03-0322-AM.png?hsLang=en)

![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-08-56-17-0399-AM.png?width=209&height=144&name=image-png-Oct-02-2026-08-56-17-0399-AM.png)

 

### **Key capabilities include:**

- Flexible relationships: set AND/OR logic between any filters or filter groups
- Drag-and-drop configuration: reorder and organize filters easily
- Sub-groups: nest filters into groups for more complex logic
- Exclude mode: exclude variants matching specific criteria by enabling the Exclude toggle on any filter
- Activation and de-activation of single filters
- Possibility to edit filters parameters from the interactive side bar

### **Configure new filter sets**

Click on the **Filters** icon ![](https://lh4.googleusercontent.com/bsJXUTKF_UgZnPcyAz7JgVvI7wFN1SWiZjHZ6gI74ybFLeFjFN4PdxVjNubkBAjQwRMZUkD974-CCmYqbgvQtAGM-U9GsbTkQYYh3YqWHlhj3vU34m-BFKBB7oaJ-IfZjEfcZSYInEJRxgcV6egRFLiPqaSUFgqi) to create and manage filter sets, which you can use on multiple samples. You can duplicate sets, reorder filters within sets or drag and drop filters from set to set.

![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-09-00-11-0478-AM.png?width=491&height=170&name=image-png-Oct-02-2026-09-00-11-0478-AM.png)

To configure and save a new filter set, click on the **Build Custom Filters** icon  ![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-09-03-41-9889-AM.png?width=144&height=30&name=image-png-Oct-02-2026-09-03-41-9889-AM.png) .

![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-09-04-12-1657-AM.png?width=592&height=631&name=image-png-Oct-02-2026-09-04-12-1657-AM.png)

A pop-up window titled **Configure Filters** will appear. This window is divided into two columns: **Available Filters** and **Filter Configuration**.

To select a filter set, drag and drop it from the **Available Filters** column to the **Filter Configuration** column.

Build complex filter logic by grouping filters into groups and subgroups, and combining them with **AND/OR** operations. Between two filters, groups, or subgroups, you can choose either **AND** or **OR**. When combining more than two filters at the same level, you can only use a single operator throughout (**all AND or all OR**). To exclude variants matching specific criteria, simply enable the Exclude option on the relevant filter. Use the visualize option to preview the advanced query and confirm the resulting logic before applying it.

Once you have finished editing your new filter set, give it a **Name** and click on **Save & Use**.

[![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-09-16-29-6651-AM.png?width=670&height=450&name=image-png-Oct-02-2026-09-16-29-6651-AM.png)](https://docs.varsome.com/hubfs/image-png-Oct-02-2026-09-16-29-6651-AM.png?hsLang=en)<https://docs.varsome.com/hubfs/image-png-Aug-07-2025-10-45-35-2871-AM.png?hsLang=en>

Please note that the **Filter Set Name** field cannot be left empty. If you do not enter a name, the following error message will appear in the top- right corner. [![](https://docs.varsome.com/hs-fs/hubfs/undefined-Oct-05-2026-11-29-35-7045-AM.png?width=670&height=241&name=undefined-Oct-05-2026-11-29-35-7045-AM.png)](https://docs.varsome.com/hubfs/undefined-Oct-05-2026-11-29-35-7045-AM.png?hsLang=en)

For example, to create a filter to show all the variants except those that are only intronic, drag and drop the **Functions** filter and then select "**intronic**" and "**intronic but not splicing**" functions as shown in the picture below.

[![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-09-21-07-6496-AM.png?width=670&height=417&name=image-png-Oct-02-2026-09-21-07-6496-AM.png)](https://docs.varsome.com/hubfs/image-png-Oct-02-2026-09-21-07-6496-AM.png?hsLang=en)

Once you enter the desired name, and click the **Save & Use** button, the filter will appear in the **ACTIVE SELECTIONS** section. Click the **Apply Filter Sets** button to apply the filter set to your analysis. 

[![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-09-26-23-7259-AM.png?width=598&height=487&name=image-png-Oct-02-2026-09-26-23-7259-AM.png)](https://docs.varsome.com/hubfs/image-png-Oct-02-2026-09-26-23-7259-AM.png?hsLang=en)

Once applied, the number of filter sets activated for the analysis will be shown in the side bar.

[![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-05-2026-11-34-46-3607-AM.png?width=670&height=154&name=image-png-Oct-05-2026-11-34-46-3607-AM.png)](https://docs.varsome.com/hubfs/image-png-Oct-05-2026-11-34-46-3607-AM.png?hsLang=en)

The sidebar displays the applied filter set, its parameters, and how those parameters relate to each other. You can edit any parameter on the fly to tailor the filter set to a specific case. These edits apply only to the current analysis; the original filter set, which may be shared across multiple analyses, remains unchanged.

[![](https://docs.varsome.com/hs-fs/hubfs/undefined-Oct-05-2026-11-43-17-5630-AM.png?width=670&height=315&name=undefined-Oct-05-2026-11-43-17-5630-AM.png)](https://docs.varsome.com/hubfs/undefined-Oct-05-2026-11-43-17-5630-AM.png?hsLang=en)

To reset filters you can always click the **Reset** button.

![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-05-2026-11-48-05-0954-AM.png?width=117&height=50&name=image-png-Oct-05-2026-11-48-05-0954-AM.png)

You can modify the name of the filter set by clicking on ![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-09-31-37-8240-AM.png?width=33&height=32&name=image-png-Oct-02-2026-09-31-37-8240-AM.png). In this example, the filter set "**Population Frequencies**" will be renamed to "**Rare Variants**":

[![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-09-33-49-3216-AM.png?width=602&height=262&name=image-png-Oct-02-2026-09-33-49-3216-AM.png)](https://docs.varsome.com/hubfs/image-png-Oct-02-2026-09-33-49-3216-AM.png?hsLang=en)

[![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-09-35-00-0576-AM.png?width=670&height=315&name=image-png-Oct-02-2026-09-35-00-0576-AM.png)](https://docs.varsome.com/hubfs/image-png-Oct-02-2026-09-35-00-0576-AM.png?hsLang=en)  
![](https://docs.varsome.com/hs-fs/hubfs/image-png-Sep-29-2022-02-08-30-47-PM.png?width=46&name=image-png-Sep-29-2022-02-08-30-47-PM.png)

[![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-09-36-10-1219-AM.png?width=670&height=310&name=image-png-Oct-02-2026-09-36-10-1219-AM.png)](https://docs.varsome.com/hubfs/image-png-Oct-02-2026-09-36-10-1219-AM.png?hsLang=en)

### **Applying an existing filter to a variant table**

Clicking on the filter icon ![](https://lh4.googleusercontent.com/bsJXUTKF_UgZnPcyAz7JgVvI7wFN1SWiZjHZ6gI74ybFLeFjFN4PdxVjNubkBAjQwRMZUkD974-CCmYqbgvQtAGM-U9GsbTkQYYh3YqWHlhj3vU34m-BFKBB7oaJ-IfZjEfcZSYInEJRxgcV6egRFLiPqaSUFgqi) it opens the **Filters** menu where filter sets can be managed. To exit this menu, simply press "**Esc**" on your keyboard.

A drop-down list will display all saved filter sets. Select one of the existing filter sets, and it will appear in the **ACTIVE SELECTION** section. In order to apply the selected filter set to the analysis, select: ![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-09-54-16-3699-AM.png?width=135&height=31&name=image-png-Oct-02-2026-09-54-16-3699-AM.png)

[![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-09-54-43-8549-AM.png?width=637&height=212&name=image-png-Oct-02-2026-09-54-43-8549-AM.png)](https://docs.varsome.com/hubfs/image-png-Oct-02-2026-09-54-43-8549-AM.png?hsLang=en)

[![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-09-55-10-6881-AM.png?width=657&height=456&name=image-png-Oct-02-2026-09-55-10-6881-AM.png)](https://docs.varsome.com/hubfs/image-png-Oct-02-2026-09-55-10-6881-AM.png?hsLang=en)

 

Please note that when you add multiple filter sets, they are always combined with **AND**.

Each of the filters inside a filter set can be switched on and off by clicking on the checkbox. Filters can be edited or removed ![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-10-03-44-8214-AM.png?width=55&height=35&name=image-png-Oct-02-2026-10-03-44-8214-AM.png) .

Click on ![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-10-07-59-8044-AM.png?width=136&height=28&name=image-png-Oct-02-2026-10-07-59-8044-AM.png) to filter the original results of the variant table. The number of variants that pass the filter is also shown under the variant table. The number of rows of the variant table can be adjusted by selecting ![](https://docs.varsome.com/hs-fs/hubfs/image-png-Sep-29-2022-02-21-43-19-PM.png?width=27&name=image-png-Sep-29-2022-02-21-43-19-PM.png).

![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-10-08-30-9997-AM.png?width=541&height=41&name=image-png-Oct-02-2026-10-08-30-9997-AM.png)

When downloading all the filtered variants from the Variant table in Excel format there will be a separate tab called “**Filters used**” that lists which filters were used.

Please note that if existing filters with ACMG rules do not work, you will see an error message returned, like the following:

![](https://docs.varsome.com/hubfs/image-png-Sep-29-2022-02-25-32-94-PM.png)

In this case you should edit (as shown above) the filter, by adding the rules you would like to have from the available options.

### **Shared Filters**

Users of the same group can now share filters among them. To share a filter with other members of your group, click **Filter sets** at the navigation bar and then click the share icon on any of the filters you wish to share. The sharing icon is a click toggle to switch between sharing status.

![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-10-23-31-3173-AM.png?width=670&height=242&name=image-png-Oct-02-2026-10-23-31-3173-AM.png)

Filters that have been shared among members of the same group appear on the **Shared Filters Sets** page and when filtering a specific analysis.

![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-10-35-06-5822-AM.png?width=255&height=62&name=image-png-Oct-02-2026-10-35-06-5822-AM.png)

Although a shared filter can be used by anyone in the group, it can only be edited by the user who initially shared the filter. Other group members can still duplicate the filter and edit it.

In the analysis results page, click on the **Filters** icon ![](https://lh4.googleusercontent.com/bsJXUTKF_UgZnPcyAz7JgVvI7wFN1SWiZjHZ6gI74ybFLeFjFN4PdxVjNubkBAjQwRMZUkD974-CCmYqbgvQtAGM-U9GsbTkQYYh3YqWHlhj3vU34m-BFKBB7oaJ-IfZjEfcZSYInEJRxgcV6egRFLiPqaSUFgqi), use the drop down list of the search box to select the shared filter of interest and then click on ![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-10-31-08-3390-AM.png?width=133&height=29&name=image-png-Oct-02-2026-10-31-08-3390-AM.png).

Please note that filter-sets sharing is only within VarSome Clinical organizations, you cannot share them, for example, with people outside your organization.

Care must be taken for shared filters because user-created filter sets are essentially composed of filter instances (e.g., a filter instance is the filtering of pathogenic variants), and filter instances can be turned on or off by the creator of the filter set. So, if the filter set is shared, other users who use this filter set may be able to apply it to their analyses, but may see that not all filter instances are enabled, and they can do nothing about it. If the original creator of the filter set chooses to, for example, disable a filter instance, then all other users who use that shared filter set will see changes in their results because of that. To avoid this, you can duplicate the shared filter set as one of your own so that you have direct access to what is enabled or not.

### **NOTES**

- The dynamic filter "**VCF filters**" is specifically for values in the **FILTER** field of the VCF file.
  
  ![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-09-38-11-2197-AM.png?width=670&height=93&name=image-png-Oct-02-2026-09-38-11-2197-AM.png)
  
  These could include "**PASS**" or "**FAIL**" or, for somatic analyses using tools like Mutect2 and FilterMutectCalls, terms like "**germline**" or "**clustered\_events**".
  
  The filter is treated as a string and these values can be found in the Filters column, as shown below.
  
  ![](https://docs.varsome.com/hs-fs/hubfs/image-png-Jan-10-2025-10-31-41-5989-AM.png?width=427&height=294&name=image-png-Jan-10-2025-10-31-41-5989-AM.png)
- In SV analyses (CNVs and/or any other type of SV analyses) you can filter the results by variant type as shown below:
  
  ![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-09-45-12-9065-AM.png?width=670&height=369&name=image-png-Oct-02-2026-09-45-12-9065-AM.png)
  
  You can also filter them based on the overlap with known SVs. More information can be found in the document [Overlap with known SV](https://docs.varsome.com/en/overlap-with-known-sv?hsLang=en).
- In somatic analyses you can filter your results based on OncoKB Oncogenicity, OncoKB Function and OncoKB levels of evidence using the following OncoKB filters.
  
  ![](https://docs.varsome.com/hs-fs/hubfs/image-png-Oct-02-2026-09-47-03-4034-AM.png?width=391&height=300&name=image-png-Oct-02-2026-09-47-03-4034-AM.png)
- **Call Status Filtering in Trio Analyses**: In a trio analysis, the Call status filter we do not filter out variants with a dot (.) genotype when at least one of the trio members (father, mother, or proband) lacks a genotype. 
  
  These cases occur when at least one of the samples does not have a genotype. In such situations, we choose not to filter out the variant, even if one or two samples pass the filter while the others do not. This approach ensures that potentially relevant variants remain in the analysis despite missing genotype data in one of the trio members.
- Examples and more information about fusions filtering can be found in the document [How can I filter and export Fusions](https://docs.varsome.com/en/how-can-i-filter-and-export-fusions?hsLang=en).

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